Ucwaningo lwamagundane luphakamisa ukuthi ukuthathauvithamini Ckungasiza ukulwa nokuwohloka kwemisipha, umphumela ovamile oseceleni wesidakamizwa se-chemotherapy i-doxorubicin.Nakuba izifundo zomtholampilo zidingeka ukuze kutholwe ukuphepha nokusebenza ngempumelelo kokuthatha uvithamini C phakathi nokwelashwa kwe-doxorubicin, okutholakele kusikisela ukuthi uvithamini C angase amele ithuba elithembisayo lokunciphisa eminye yemiphumela emibi ewohloza kakhulu yomuthi.
Okutholakele kwethu kusikisela ukuthi uvithamini C uyindlela yokwelapha engaba khona ukusiza ukwelapha isifo sezicubu ze-peripheral kulandela ukwelashwa kwe-doxorubicin, ngaleyo ndlela kuthuthukiswe amandla okusebenza kanye nezinga lempilo nokunciphisa ukufa.
U-Antonio Viana do Nascimento Filho, M.Sc., Universidad Nova de Julio (UNINOVE), Brazil, umbhali wokuqala wocwaningo, uzokwethula okutholwe emhlanganweni waminyaka yonke we-American Physiological Society ngesikhathi somhlangano we-2022 Experimental Biology (EB) ePhiladelphia, ngo-Ephreli 2-5.
I-Doxorubicin iyisidakamizwa se-anthracycline ngamakhemikhali esivame ukusetshenziswa nezinye izidakamizwa ze-chemotherapy ukwelapha umdlavuza webele, umdlavuza wesinye, i-lymphoma, i-leukemia, nezinye izinhlobo zomdlavuza eziningana.Nakuba kuwumuthi osebenza ngempumelelo wokulwa nomdlavuza, i-doxorubicin ingabangela izinkinga ezinkulu zenhliziyo kanye nokuwohloka kwemisipha, kube nemiphumela ehlala njalo emandleni omzimba wabasindile kanye nezinga lempilo.
Le miphumela engemihle kucatshangwa ukuthi ibangelwa ukukhiqizwa ngokweqile kwezinto ezisebenza umoya-mpilo noma "ama-radicals mahhala" emzimbeni.Ivithamini Ciyi-antioxidant yemvelo engasiza ekunciphiseni ukucindezeleka kwe-oxidative, uhlobo lomonakalo obangelwa ama-radicals mahhala.
Ocwaningweni lwangaphambilini neNyuvesi yaseManitoba eCanada, ithimba lathola ukuthi i-vitamin C ithuthukise izimpawu zezempilo yenhliziyo nokuphila kwamagundane anikezwe i-doxorubicin, ngokuyinhloko ngokunciphisa ukucindezeleka kwe-oxidative nokuvuvukala.Ocwaningweni olusha, bahlole ukuthi uvithamini C angasiza yini ukuvimbela imiphumela emibi ye-doxorubicin emisipha yamathambo.
Abacwaningi baqhathanisa imisipha ye-skeletal muscle kanye nezimpawu zokucindezeleka kwe-oxidative emaqenjini amane amagundane, ngayinye ye-8 kuya kwezilwane ze-10.Iqembu elilodwa labathatha bobabiliuvithamini Cfuthi i-doxorubicin, iqembu lesibili lathatha i-vitamin C kuphela, iqembu lesithathu lathatha i-doxorubicin kuphela, kanti iqembu lesine alizange lithathe noma yikuphi.Amagundane anikezwe uvithamini C kanye ne-doxorubicin abonise ubufakazi bokuncipha kwengcindezi ye-oxidative kanye nesisindo somzimba esingcono uma kuqhathaniswa namagundane anikezwe i-doxorubicin kodwa hhayi i-vitamin C.
“Kuyajabulisa ukuthi ukwelashwa kwe-prophylactic kanye nokuhambisana ne-vitamin C okunikezwa isonto elilodwa ngaphambi kwe-doxorubicin kanye namasonto amabili ngemuva kwe-doxorubicin kwanele ukunciphisa imiphumela emibi yalo muthi emisipha yohlaka lwamathambo, ngaleyo ndlela kwehlise umphumela omuhle kakhulu kumisipha yamathambo.Ukutadisha impilo yezilwane,” kusho uNascimento Filho.”Umsebenzi wethu ubonisa ukuthi ukwelashwa kukavithamini C kunciphisa ukuncipha kwemisipha futhi kuthuthukisa izimpawu eziningi zokungalingani kwamagundane athola i-doxorubicin.”
Ososayensi baphawule ukuthi ucwaningo olwengeziwe, okuhlanganisa nokuhlolwa komtholampilo okungahleliwe, kuyadingeka ukuze kuqinisekiswe ukuthi ukuthatha uvithamini C ngesikhathi sokwelashwa kwe-doxorubicin kuyasiza ezigulini ezingabantu kanye nokunquma umthamo ofanele kanye nesikhathi.Ucwaningo lwangaphambilini luveza ukuthi uvithamini C angase aphazamise imiphumela yemithi yokwelapha ngamakhemikhali, ngakho iziguli azilulekwa ukuthi zidle izithasiselo zikavithamini C lapho zelashwa umdlavuza ngaphandle uma ziqondiswa udokotela wazo.
Isikhathi sokuthumela: Apr-26-2022