Source: 39 Health Network
Core tip: when cephalosporin antibiotics and some hypoglycemic drugs meet with alcohol, they can lead to “disulfiram like” poisoning reaction. The misdiagnosis rate of this kind of poisoning reaction is as high as 75%, and those who are serious can die. The doctor reminds that you should not drink alcohol within two weeks after taking antibiotics, and do not touch alcoholic food and drugs such as Huoxiang Zhengqi water and Jiuxin chocolate.
Fever and cold were held at home for several days. After treatment, about 35 confidants drank together; After eating hypoglycemic drugs, drink a little wine to relieve cravings… This is not uncommon for many men. However, experts cautioned against being put down by “a little wine” after illness.
In the past month, many men in Guangzhou have drunk symptoms such as palpitation, chest tightness, sweating, dizziness, abdominal pain and vomiting on the wine table. However, when they went to the hospital, they found that they had no alcoholism, cardiovascular and cerebrovascular diseases and other problems. It turned out that before they went to dinner, they had taken antibiotics and hypoglycemic drugs.
Doctors pointed out that after taking cephalosporin antibiotics, imidazole derivatives, sulfonylureas and biguanides, once exposed to alcohol, it will lead to this “disulfiram like reaction” which has been neglected for a long time in clinical practice. In severe cases, it can lead to respiratory failure and even death. The doctor reminded that you should not drink alcohol within two weeks after eating antibiotics, do not touch Huoxiang Zhengqi water and Jiuxin chocolate, and be careful to use yellow rice wine when cooking.
Acetaldehyde poisoning induced by alcohol
Disulfiram is a catalyst in the rubber industry. As early as 63 years ago, researchers in Copenhagen found that if people exposed to this substance drink, they can have a series of symptoms such as chest tightness, chest pain, palpitation and shortness of breath, facial flushing, headache and dizziness, abdominal pain and nausea, so they named it “disulfiram like reaction”. Later, disulfiram was developed into a drug for abstaining from alcohol, which made alcoholics dislike alcohol and get rid of alcohol addiction.
Some pharmaceutical ingredients also contain chemicals with a chemical structure similar to disulfiram. After ethanol enters the human body, the normal metabolic process is to oxidize into acetaldehyde in the liver, and then oxidize into acetic acid. Acetic acid is easy to be further metabolized and discharged out of the body. However, disulfiram reaction makes acetaldehyde unable to be further oxidized to acetic acid, resulting in acetaldehyde accumulation in the drug users, thus inducing poisoning.
Post time: Aug-20-2021