Ingena kuI-JAMA kanye ne-Archives Journals,ukuhlolwa kwe-morden okukhethwe ngokungahleliwe odokotela besilisa be-15,000 kubonisa ukuthi ukusetshenziswa kwe-multivitamin yesikhathi eside ekuphileni kwansuku zonke iminyaka engaphezu kweshumi yokwelashwa kunganciphisa ngokuphawulekayo amathuba okuthola umdlavuza.
“Amavithamini amaningiziyizithasiselo zokudla ezivame kakhulu, ezivame ukuthathwa okungenani ingxenye eyodwa kwezintathu yabantu abadala base-US.Indima yendabuko ye-multivitamin yansuku zonke ukuvimbela ukuntuleka komsoco.Inhlanganisela yamavithamini namaminerali abalulekile aqukethwe kuma-multivitamin ingase ibonise izindlela zokudla ezinempilo ezifana nokudla kwezithelo nemifino, okuye kwahlotshaniswa ngesizotha futhi ngokuphambene nengozi yomdlavuza kwezinye, kodwa hhayi zonke, izifundo ze-epidemiologic.Izifundo zokubheka zokusetshenziswa kwe-multivitamin isikhathi eside kanye namaphuzu okuphela komdlavuza bekulokhu kungahambisani.Kuze kube manje, izivivinyo ezinkulu ezingahleliwe ezihlola inombolo eyodwa noma encane yamavithamini namaminerali anesilinganiso esiphezulu somdlavuza ngokuvamile zithole ukuntuleka komphumela, ”kusho imininingwane yangemuva kujenali.“Naphezu kokushoda kwedatha yesilingo esiqondile mayelana nezinzuzo zeamavithamini amaningiekuvimbeleni izifo ezingamahlalakhona, kuhlanganise nomdlavuza, amadoda nabesifazane abaningi bazithatha ngenxa yalesi sizathu.”
J. Michael Gaziano, MD, MPH, waseBrigham and Women’s Hospital kanye ne-Harvard Medical School, eBoston, (kanye noMhleli Onikelayo,JAMA), kanye nozakwethu bahlaziya idatha evela ku-Physicians' Health Study (PHS) II, okuwukuphela kwesivivinyo esikhulu, esingahleliwe, esingaboni kabili, esilawulwa yi-placebo imiphumela yesikhathi eside ye-multivitamin evamile ekuvimbeleni isifo esingamahlalakhona.Lokhu kuhlolwa kumeme odokotela besilisa base-US abangu-14,641 abadala kuneminyaka engama-50, okuhlanganisa namadoda ayi-1,312 anomdlavuza emlandweni wabo wezokwelapha.Babhaliswe ocwaningweni lwe-multivitamin olwaqala ngo-1997 ngokwelashwa nokulandelela kuze kube nguJuni 1, 2011. Abahlanganyeli bathola i-multivitamin yansuku zonke noma i-placebo efanayo.Umphumela oyinhloko olinganisiwe wocwaningo kwaba umdlavuza ophelele (ngaphandle komdlavuza wesikhumba ongenayo i-melanoma), one-prostate, i-colorectal, neminye imidlavuza eqondene nendawo ethile phakathi kwezindawo zokugcina zesibili.
Abahlanganyeli be-PHS II balandelwa ngokwesilinganiso seminyaka eyi-11.2.Ngesikhathi sokwelashwa ngamavithamini angu-2,669 aqinisekisiwe omdlavuza, okuhlanganisa nezigameko ezingu-1,373 zomdlavuza we-prostate kanye namacala angu-210 omdlavuza we-colorectal, kanti amanye amadoda abe nezenzakalo eziningi.Isamba samadoda angu-2,757 (amaphesenti angu-18.8) ashona ngesikhathi sokulandelela, kuhlanganise nama-859 (amaphesenti angu-5.9) ngenxa yomdlavuza.Ukuhlaziywa kwedatha kubonise ukuthi amadoda athatha i-multivitamin abe nokwehliswa okulinganiselwe kwamaphesenti angu-8 ezimweni zomdlavuza eziphelele.Amadoda athatha i-multivitamin abe nokuncipha okufanayo kwengqikithi yomdlavuza we-epithelial cell.Cishe isigamu sazo zonke izigameko zomdlavuza kwakungumdlavuza wendlala yesinye, eziningi zazo okwakuyisigaba sokuqala.Abacwaningi abatholanga umphumela we-multivitamin kumdlavuza we-prostate, kanti i-multivitamin yehlisa kakhulu ingozi yomdlavuza ophelele ngaphandle komdlavuza we-prostate.Akubangakho ukuncipha okuphawulekayo komdlavuza wendawo ngayinye, okuhlanganisa umdlavuza we-colorectal, wamaphaphu, nowesinye, noma ekufeni komdlavuza.
Ukusetshenziswa kwama-multivitamin nsuku zonke kwahlotshaniswa nokuncishiswa komdlavuza ophelele phakathi kwamadoda ayi-1,312 anomlando wokuqala womdlavuza, kodwa lo mphumela awuzange uhluke kakhulu kulowo owabonwa phakathi kwabesilisa be-13,329 ekuqaleni abangenawo umdlavuza.
Abacwaningi baphawula ukuthi inani lomdlavuza esivivinyweni sabo kungenzeka lithonywe ukwanda kokubhekwa kwe-prostate-specific antigen (PSA) kanye nokuxilonga okwalandela komdlavuza wendlala yesinye ngesikhathi sokulandelwa kwe-PHS II kusukela ngasekupheleni kwawo-1990.“Cishe ingxenye yawo wonke ama-cancer aqinisekisiwe ku-PHS II kwakungumdlavuza wendlala yesinye, iningi lawo ebelisesigabeni sangaphambili, umdlavuza we-prostate osezingeni eliphansi onamazinga aphezulu okusinda.Ukuncipha okuphawulekayo komdlavuza ophelele ususa umdlavuza wendlala yesinye kuphakamisa ukuthi ukusetshenziswa kwamavithamini nsuku zonke kungase kube nenzuzo enkulu ekuxilongeni umdlavuza okuhlobene kakhulu nomtholampilo.”
Ababhali banezela ukuthi yize amavithamini namaminerali amaningi ngamanye aqukethwe ocwaningweni lwe-PHS II lwe-multivitamin eveze izindima ze-chemopreventive, kunzima ukukhomba ngokuphelele noma iyiphi indlela eyodwa yomphumela lapho izingxenye ezithile noma eziningi ze-multivitamin yazo ehloliwe zinganciphisa ubungozi bomdlavuza."Ukuncipha kwengozi yomdlavuza ku-PHS II ithi inhlanganisela ebanzi yamavithamini namaminerali anedosi ephansi equkethwe ku-PHS II multivitamin, kunokuba kugcizelelwe ekuhlolweni kwangaphambili kwemithamo ephezulu yamavithamini kanye nezivivinyo zamaminerali, kungase kubaluleke kakhulu ekuvimbeleni umdlavuza. .… Iqhaza lesu lokuvinjelwa komdlavuza eligxile ekudleni elifana nokudla okuhlosiwe kwezithelo nemifino lihlala lithembisa kodwa lingafakazelwa uma kubhekwa ubufakazi obungaguquki be-epidemiologic kanye nokuntuleka kwedatha yocwaningo oluqondile.”
"Nakuba isizathu esiyinhloko sokuthatha ama-multivitamins ukuvimbela ukuntuleka kokudla okunomsoco, le datha ihlinzeka ngokusekela ukusetshenziswa okungenzeka kwe-multivitamin supplements ekuvimbeleni umdlavuza emadodeni aneminyaka ephakathi nangaphezulu," kuphetha abacwaningi.
Isikhathi sokuthumela: Apr-19-2022