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An ampoule of ranitidine contains rannitidine hydrochloride USP XXIII 50 mg.
Ranitidine is a histamine H2-receptor antagonist,Accordingly, it inhibits gastric acid secretion and reduces pepsin output: it has been shown to inhibit other actions of histamine mediated by H2-receptors, It is used in the management of various gastro-intestinal disorders such as aspiration syndromes, dyspepsia, gastro-oesophageal reflux disease, peptic ulceration and Zollinger-Ellison syndrome.
Before giving ranitidine to patients with gastrle ulcers the possibility of malignancy should be excluded since ranitidine may mask symtoms and delay diagnosis. It should be given in reduced dosage to patients with impaired renal function.
The commonest side-effects reported have been diarrhoca,dizziness,headache,and rashes.Other adverse effects,which have been reported rarely,are hypersensilivity reactions and fever,arthralgia and myalgia.Blood disorders including agranulocytosis or neutropenia and thrombocytopenia,interstitial nephritis, hepatotoxicity, and cardiovascular disorders,however,unlike cimetidine,ranitidine has little or no anti-andiogenic effect,although there have been isolated reports of gyhaecomaslia and impotence
Dosage and Administration
Depending on the condition being treated the usual dose by intramuscular or intravenous injecton is 50 mg, which may be repeated every 6 to 8 hours: the inravenous injection should be given slowly over not less than 2 minutes and should be diluted to contain 50 mg in 20ml for an intermittent intravenous infusion the recommended dose in the UK is 25 mg per hour given for 2hours which may be repeated every 6 to 8 hours a rate of 6.25mg per hour has been suggested for continuous intravenous infusion although higher rates may be employed for conditions such as Zollinger-Ellison syndrome or in patients at risk from stress alceration.
Storage and Expired Time
Store below 25℃.