Marasa lafiya marasa ƙarfi tare da novel coronavirus ciwon huhu: heparin anticoagulation vs rigakafin thrombus na al'ada

Tushen: Lokacin tattara magungunan duniya: Satumba 18, 2021

Yawancin marasa lafiya na ciwon huhu na coronavirus suna da matsakaicin rashin lafiya kuma da farko basa buƙatar tallafin gabbai a cikin ICU.An yi amfani da novel coronavirus pneumonia a cikin binciken N Engl J Med a watan Agusta 2021. Masu bincike a Kanada, Amurka da Brazil sun buga tsoffin adabin Sinawa don neman sakamakon maganin rigakafin ciwon huhu na heparin anticoagulant a cikin marasa lafiya marasa lafiya da sabon kambi.

Fage: novel coronavirus pneumonia yana da alaƙa da mutuwa da rikitarwa saboda thrombosis da kumburi.Masu binciken sun yi hasashen novel coronavirus ciwon huhu zai iya inganta sakamakon marasa lafiya marasa lafiya da ke da sabon ciwon huhu.

Hanyoyi: novel coronavirus pneumonia (ba goyon bayan gabobin jiki), wanda aka ayyana azaman matakin kulawa mai mahimmanci, an ba shi da kayyade zuwa ma'anoni 2 masu amfani: heparin anticoagulation ko na yau da kullun na thrombus prophylaxis a cikin wannan buɗewa, daidaitawa, dandamali mai yawa, gwajin sarrafawa.Sakamakon farko shine adadin kwanakin ba tare da goyon bayan gabobin jiki ba, wanda aka kiyasta ta hanyar ma'auni mai mahimmanci wanda ya haɗu da mutuwar asibiti (maki - 1) da adadin kwanakin marasa lafiya da suka tsira don fitarwa ba tare da tallafin zuciya da jijiyoyin jini ko na numfashi ba har zuwa ranar 21. An kimanta duk sakamakon haƙuri ta amfani da samfuran ƙididdiga na Bayesian kuma bisa tushen matakan D-dimer.

Sakamako: lokacin da adadin maganin rigakafin ciwon zuciya ya cika ka'idodin fifikon da aka saita, an dakatar da gwajin.Daga cikin marasa lafiya na 2219 a cikin bincike na ƙarshe, yiwuwar maganin maganin maganin rigakafi yana ƙaruwa da adadin kwanakin ba tare da tallafin kwayoyin halitta ba idan aka kwatanta da thromboprophylaxis na al'ada shine 98.6% (daidaita ko, 1.27; 95% CI, 1.03 ~ 1.58).Cikakken bambanci tsakanin ƙungiyoyi a cikin daidaitawa na rayuwa don fitarwa ba tare da goyon bayan gabobin jiki ya nuna cewa maganin maganin maganin rigakafi ya fi kyau, kuma bambanci tsakanin ƙungiyoyi biyu shine 4.0% (0.5 ~ 7.2).Yiwuwar ƙarshe na fifikon maganin rigakafin maganin warkewa akan thromboprophylaxis na al'ada shine 97.3%, 92.9% da 97.3% a cikin babban ƙungiyar D-dimer, ƙaramin ƙungiyar D-dimer da ƙungiyar D-dimer da ba a san su ba, bi da bi.Yawan zubar da jini ya faru a cikin 1.9% da 0.9% na marasa lafiya a cikin rukunin maganin rigakafi da ƙungiyar rigakafin thrombosis, bi da bi.

Kammalawa: sabon dabarun cutar ciwon huhu na coronavirus na iya ƙara yuwuwar rayuwa da fitarwa da rage amfani da tallafin zuciya da jijiyoyin jini ko na numfashi a cikin marasa lafiya marasa sabon ciwon huhu.


Lokacin aikawa: Satumba 18-2021